Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FE65: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Protein profile: FE65 Protein - APBB1, an adaptor protein involved in APP processing and Alzheimer's disease pathogenesis
| Gene Symbol | FE65 |
| Aliases | Protein profile: FE65 Protein |
| Function | FE65 contains multiple protein-protein interaction domains including a WW domain and two phosphotyrosine-binding (PTB) domains, allowing it to function as a molecular scaffold linking APP to divers... |
| Subcellular Localization | Signals (NLS)**: FE65 can translocate to the nucleus where it functions as a tra |
| Molecular Weight | 60 kDa |
| Amino Acids | 580 aa |
| Pathways | oxidative stress response, cholesterol homeostasis, blood-brain barrier |
| GeneCards | FE65 |
| Human Protein Atlas | FE65 |
| Interactions | APP |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FE65(["FE65"])
style FE65 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
LRP1["LRP1"]
oxidative_stress_response(("oxidative stress response"))
cholesterol_homeostasis(["cholesterol homeostasis"])
blood_brain_barrier["/"blood-brain barrier"/"]
neurons["/"neurons"/"]
FE65 -->|"regulates"| LRP1
FE65 -->|"participates_in"| oxidative_stress_response
FE65 -->|"participates_in"| cholesterol_homeostasis
FE65 -->|"participates_in"| blood_brain_barrier
FE65 -->|"expressed_in"| neurons
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class LRP1 gene
class oxidative_stress_response pathway
class cholesterol_homeostasis protein
class blood_brain_barrier mechanism
class neurons mechanism| Target | Relation | Type | Str |
|---|---|---|---|
| LRP1 | regulates | gene | 0.55 |
| oxidative stress response | participates_in | pathway | 0.55 |
| cholesterol homeostasis | participates_in | pathway | 0.55 |
| blood-brain barrier | participates_in | pathway | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APP | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||