entity

cholesterol homeostasis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about cholesterol homeostasis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

2Outgoing

43Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Outgoing (2)

Target	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.85
AUTOPHAGY	associated_with	process	0.80

Incoming (46)

Source	Relation	Type	Str
SREBF2	regulates	gene	0.90
ABCA1	participates_in	gene	0.85
LXR	participates_in	gene	0.85
neurons	active_in	cell_type	0.85
SREBP2	regulates	gene	0.85
APOE	regulates	gene	0.80
YTHDF2	inhibits	protein	0.80
HUNTINGTON	disrupts	disease	0.80
neuroinflammation	involves	disease	0.75
APOE	participates_in	gene	0.75
APOE4	participates_in	gene	0.75
LAMP2	regulates	protein	0.75
ATP	participates_in	gene	0.75
CYP46A1	participates_in	gene	0.65
ABCG1	participates_in	gene	0.65
LRP1	participates_in	gene	0.65
CYP46A1	regulates	gene	0.60
HMGCR	involved_in	protein	0.60
ABCA7	regulates	gene	0.60
NPC1	participates_in	gene	0.55
ABCA7	participates_in	gene	0.55
TREM2	participates_in	gene	0.55
GABARAPL1	participates_in	gene	0.55
FASN	participates_in	gene	0.55
HK2	participates_in	gene	0.55
SQSTM1	participates_in	gene	0.55
SP1	participates_in	gene	0.55
SGMS1	participates_in	gene	0.55
HMGCR	participates_in	gene	0.55
APP	participates_in	gene	0.55
LDLR	participates_in	gene	0.55
DGAT1	participates_in	gene	0.55
SOAT1	participates_in	gene	0.55
TNF	participates_in	gene	0.55
Alzheimer's disease	involves	disease	0.55
oligodendrocytes	active_in	cell_type	0.55
LDHA	participates_in	gene	0.55
PKM	participates_in	gene	0.55
ACSL5	participates_in	gene	0.55
astrocytes	active_in	cell_type	0.55
PS1	participates_in	gene	0.55
FE65	participates_in	gene	0.55
microglia	active_in	cell_type	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

cholesterol homeostasis

Understanding Entity Pages

Wiki Pages (20)

Oligodendrocytes

APOC4 — Apolipoprotein C-IV

TREM2 Microglial Signaling Pathway in Neurodegeneration

Niemann-Pick Disease Type C (NPC)

metabolic-dysfunction-neurodegeneration

Metabolomic Alterations in PSP

Lipid Metabolism Dysregulation in Neurodegeneration

Alzheimer's Disease Synaptic Repair and Neuroprotection Companies

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

niemann-pick-disease

BIN1 — Bridging Integrator 1

CAV1

SORL1 Gene

Lipid Raft Dysfunction in Neurodegeneration

ABCA7 Protein

Parkinson's Disease Metabolism

FBXO7 Protein (PARK15)

PICALM — Phosphatidylinositol Binding Clathrin Assembly Protein

ABCA7 (ATP-Binding Cassette Transporter A7)

Metabolic Dysfunction in 4R-Tauopathies

Outgoing (2)

Incoming (46)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)