gene 1,335 words KG: ABCG4 2026-03-24
kind:genesection:genesstate:published
Contents

ABCG4 Gene — ATP-Binding Cassette Subfamily G Member 4

🧬 Gene Info
Gene SymbolABCG4
Full NameABCG4 — ATP-Binding Cassette Subfamily G Member 4
AliasesATP-Binding Cassette Subfamily G Member 4
Chromosome11q22.3
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain and is involved in cholesterol and lipid transport, with emerging roles in neurodegenerative disease pathogenesis
Molecular Weight71 kDa
Amino Acids646 aa
Exons13
NCBI Gene IDSearch NCBI
GeneCardsABCG4
Human Protein AtlasABCG4
Associated Diseasesneurodegeneration
InteractionsRas
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (11)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Membrane Cholesterol Gradient Modulators
Score: 0.52
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (7)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (14)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: regulates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: regulates
ABCG1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

ABCG4 regulates ABCA1
ABCG4 regulates ABCG1
ABCG4 regulates APOE
ABCG4 regulates Alzheimer
ABCG4 regulates Als
ABCG4 regulates Cholesterol
ABCG4 activates Neuron
ABCG4 regulates Astrocyte
ABCG4 regulates ASTROCYTES
ABCG4 regulates ALS