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Cell: Hippocampal CA1 Pyramidal Neurons
cell
664 words
KG: CA1
2026-03-24
kind:cell-type
section:cell-types
state:published
Contents
Hippocampal CA1 Pyramidal Neurons
🧫
Cell Type Info
Cell Type
Hippocampal CA1 Pyramidal Neurons
Also Known As
CA-I, Carbonate dehydratase I
Key Pathways
pH regulation, CO2 transport
Associated Diseases
Metabolic acidosis
Related Genes
GABRA1
,
AMYLOID
Linked Hypotheses
73 hypotheses
Knowledge Graph
Related Hypotheses (16)
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.41
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39
Synaptic Vesicle Tau Capture Inhibition
Score: 0.34
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.41
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.38
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu
Score: 0.47
Show 11 more
Related Analyses (18)
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · completed
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Show 13 more
Related Experiments (12)
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40
Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Proteasome-Ubiquitin System Dysfunction Validation in Parkin
clinical · proposed · Score: 0.40
Protein Aggregation Kinetic Validation Results
validation · proposed · Score: 0.40
Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40
Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Show 7 more
See Also (14)
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: co_discussed
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: expressed_in
adam17
gene · KG edge: expressed_in
ACTB Gene
gene · KG edge: expressed_in
ACE Gene
gene · KG edge: expressed_in
ABI3 Gene
gene · KG edge: expressed_in
ABCG4 Gene — ATP-Binding Cassette Subfamily G Member 4
gene · KG edge: expressed_in
ABCG1 Gene
gene · KG edge: expressed_in
ABCA2 Gene - ATP Binding Cassette Subfamily A Member 2
gene · KG edge: expressed_in
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: expressed_in
GFAP (Redirect)
redirect · KG edge: protects_against
ABCA7 (Redirect)
redirect · KG edge: expressed_in
Show 9 more
Knowledge Graph (12 edges)
CA1
co_discussed
CORTEX
CA1
co_discussed
CX3CR1
CA1
co_discussed
STRIATUM
CA1
protects_against
GFAP
CA1
protects_against
NEURON
CA1
protects_against
NEURONS
CA1
protects_against
PYRAMIDAL
CA1
co_discussed
FRONTAL
CA1
co_discussed
PREFRONTAL
CA1
co_discussed
DEPRESSION