| Gene Symbol | ABCA1 |
| Full Name | ATP-Binding Cassette Transporter A1 |
| Chromosome | 9q31.1 |
| Protein Type | Transporter |
| Target Class | Transporter |
| Function | is a full-size ABC transporter with a classic architecture |
| Mechanism of Action | Small molecule modulators to enhance cholesterol efflux and HDL formation |
| Primary Expression | Brain (astrocytes, microglia, neurons), liver, macrophages, intestine |
| Druggability | Medium (0.47) |
| Clinical Stage | Approved |
| Molecular Weight | ~270 kDa |
| Amino Acids | 2,461 amino acids |
| Exons | 50 |
| Pathways | Cholesterol, Epigenetic, Lipid Metabolism, Microrna, Mitochondrial Function |
| UniProt ID | O95477 |
| NCBI Gene ID | 19 |
| Ensembl ID | ENSG00000165029 |
| GeneCards | ABCA1 |
| Human Protein Atlas | ABCA1 |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | 25-Hydroxycholesterol, CS-6253, dexamethasone, quercetin, statins |
| Interactions | 4E-BP1, abca2, ABCA2, ABCA4, ABCA7, ABCG1 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | HDL/apoE Particle Remodeling as a Therapeutic Swit APOE4 hypolipidation and ABCA1 mistrafficking impa ABCA1 Upregulation via LXRβ Agonism to Enhance Cho (+1 more) |
| KG Connections | 1179 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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