gene 1,970 words KG: ABIN1 2026-03-27
section:geneskind:genetopic:alzheimerstopic:parkinsons
Contents

ABIN1 (TNIP1) Gene

🧬 Gene Info
Gene SymbolABIN1 (TNIP1)
Full NameTNFAIP3 Interacting Protein 1
Chromosome5q33.1
Functionencodes a ubiquitin-binding protein that serves as a critical negative regulator of nuclear factor kappa B (NF-κB) signaling.
Amino Acids460 aa
Exons13
PathwaysNF-κB, NF-κB signaling
UniProt IDQ9Y5J7
NCBI Gene ID10672
Ensembl IDENSG00000134250
OMIM607416
Gene Length22.5 kb
mRNA Length3.4 kb
NF-κB InhibitorsPreclinical
A20/TNIP1 ModulatorsEnhance ABIN1-TNFAIP3 interaction
Associated Diseasesdepression
InteractionsNF-ΚB, NFKB
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
APOE-TREM2 Interaction Modulation
Score: 0.48

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Ubiquitin
protein · KG edge: regulates
nfkb-neurodegeneration
mechanism · KG edge: inhibits
TOLLIP — Toll-Interacting Protein
gene · KG edge: regulates
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates

Knowledge Graph (12 edges)

ABIN1 regulates INFLAMMATION
ABIN1 inhibits NF-ΚB
ABIN1 regulates AUTOPHAGY
ABIN1 regulates Inflammation
ABIN1 regulates Autophagy
ABIN1 inhibits Nf-Κb
ABIN1 data_in benchmark_ot_ad_answer_key:ABIN1
ABIN1 regulates PI3K
ABIN1 regulates AKT
ABIN1 associated_with depression