gene 838 words KG: TOLLIP 2026-03-24
kind:genesection:genesstate:published
Contents

TOLLIP — Toll-Interacting Protein

🧬 Gene Info
Gene SymbolTOLLIP
Full NameToll-Interacting Protein
AliasesIL-1RAcPIP
Chromosome11p15.5
FunctionIt binds and inhibits IL-1 receptor-associated kinase 1 (IRAK1), preventing its auto-phosphorylation and blocking downstream NF-kappaB and MAPK cascades.
Molecular Weight30 kDa
Amino Acids274 aa
Exons6
PathwaysMAPK
UniProt IDQ9H0E2
NCBI Gene ID54472
Ensembl IDENSG00000078902
OMIM606277
GeneCardsTOLLIP
Human Protein AtlasTOLLIP
Associated DiseasesAD, ALI, AMI, Als, Ftd, ILD
InteractionsSQSTM1, NDP52, TAX1BP1, FUS, LC3, ACTB
KG Connections195 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Phase-Separated Organelle Targeting
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Stress Granule Phase Separation Modulators
Score: 0.49
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48

Related Analyses (8)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (9)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: causes
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
BECN1 Gene
gene · KG edge: activates
ACTB Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

TOLLIP interacts_with SQSTM1
TOLLIP interacts_with NDP52
TOLLIP interacts_with TAX1BP1
TOLLIP interacts_with FUS
TOLLIP inhibits CGAS
TOLLIP participates_in selective autophagy
TOLLIP interacts_with LC3
TOLLIP interacts_with ACTB
TOLLIP implicated_in degenerative disease
TOLLIP implicated_in neurodegenerative disease