gene 1,761 words KG: ARNT2 2026-03-25
kind:genesection:genesstate:published
Contents

ARNT2 - Aryl Hydrocarbon Receptor Nuclear Translocator 2

🧬 Gene Info
Gene SymbolARNT2
Full NameAryl Hydrocarbon Receptor Nuclear Translocator 2
AliasesARNT2 gene
Chromosome15q21.3
Functionencodes a critical bHLH-PAS (basic Helix-Loop-Helix-Period Arnt-Single-minded) domain transcription factor that serves as a shared partner for multiple hypoxia-sensitive and circadian rhythm regula...
Molecular Weight79 kDa
Amino Acids710 aa
Exons24
UniProt IDQ9W2E6
NCBI Gene ID10638
Ensembl IDENSG00000150457
OMIM606994
GeneCardsARNT2
Human Protein AtlasARNT2
bHLH Domain (aa 1-60)Basic region for DNA binding and helix-loop-helix for protein dimerization
Associated Diseasesneurodegeneration
InteractionsSST, ACC
KG Connections26 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.83
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.81
Circadian Clock-Autophagy Synchronization
Score: 0.76

Related Analyses (4)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

See Also (11)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: therapeutic_target
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
TCF7L2 (Transcription Factor 7-Like 2)
gene · KG edge: transports

Knowledge Graph (12 edges)

ARNT2 expressed_in SST
ARNT2 activates Pyramidal
ARNT2 activates SST
ARNT2 expressed_in Pyramidal Cell
ARNT2 regulates Rb
ARNT2 transports NCOR1
ARNT2 transports TCF7L2
ARNT2 transports MITF
ARNT2 regulates Interneuron
ARNT2 regulates Neuron

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