concept

PYRAMIDAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PYRAMIDAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

220Connections

2Hypotheses

0Analyses

19Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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💡 Concept Info

Name	PYRAMIDAL
Key Genes/Proteins	ACHE
Related Diseases	ALS

Pathway Diagram

graph TD
    PYRAMIDAL["PYRAMIDAL"]
    style PYRAMIDAL fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PYRAMIDAL -->|"expressed in"| Cortex((Cortex))
    PYRAMIDAL -->|"expressed in"| Spinal_Cord((Spinal Cord))
    PYRAMIDAL -->|"expressed in"| Temporal_Lobe((Temporal Lobe))
    PYRAMIDAL -->|"expressed in"| Hippocampus((Hippocampus))
    PYRAMIDAL -->|"expressed in"| Prefrontal_Cortex((Prefrontal Cortex))
    NEURODEGENERATION["NEURODEGENERATION"] -->|"contributes to"| PYRAMIDAL
    ASTROCYTE["/ASTROCYTE/"] -->|"expressed in"| PYRAMIDAL
    ASTROCYTES["/ASTROCYTES/"] -->|"expressed in"| PYRAMIDAL
    MICROGLIA["/MICROGLIA/"] -->|"expressed in"| PYRAMIDAL
    CORTEX((CORTEX)) -->|"reduces"| PYRAMIDAL
    DNA_DAMAGE["DNA DAMAGE"] -->|"reduces"| PYRAMIDAL
    NEURON["/NEURON/"] -->|"reduces"| PYRAMIDAL
    NEURONS["/NEURONS/"] -->|"reduces"| PYRAMIDAL

Outgoing (19)

Target	Relation	Type	Str
SOD1	co_discussed	entity	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
SUBSTANTIA NIGRA	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
Temporal Lobe	expressed_in	brain_region	0.50
Prefrontal Cortex	expressed_in	brain_region	0.50
SYNAPSE	co_discussed	entity	0.50
SCHIZOPHRENIA	co_discussed	entity	0.50
THALAMUS	co_discussed	entity	0.50
Spinal Cord	expressed_in	brain_region	0.50
Hippocampus	expressed_in	brain_region	0.50
SQSTM1	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
Cortex	expressed_in	brain_region	0.50
STROKE	co_discussed	entity	0.50

Incoming (201)

Source	Relation	Type	Str
NEURON	contributes_to	cell_type	0.65
ASTROCYTES	expressed_in	cell_type	0.65
MICROGLIA	expressed_in	cell_type	0.65
ASTROCYTE	expressed_in	cell_type	0.65
NEURONS	reduces	cell_type	0.65
CORTEX	reduces	brain_region	0.65
NEURON	reduces	cell_type	0.65
NEURODEGENERATION	contributes_to	disease	0.65
APP/PS1	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
DRD2	activates	gene	0.60
SPTLC1	activates	gene	0.60
PTEN	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
TAU	regulates	gene	0.60
KCNN3	associated_with	gene	0.60
CAV1	associated_with	gene	0.60
ARNT2	activates	gene	0.60
SST	regulates	gene	0.60
SST	activates	gene	0.60
DRD2	expressed_in	gene	0.60
KCNH7	interacts_with	gene	0.60
STROKE	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
NEURONS	expressed_in	cell_type	0.60
FMR1	activates	gene	0.60
CA1	protects_against	brain_region	0.60
GFAP	protects_against	gene	0.60
NEURON	protects_against	cell_type	0.60
NEURONS	protects_against	cell_type	0.60
ACHE	protects_against	gene	0.60
TREM2	inhibits	gene	0.60
NEURON	expressed_in	cell_type	0.60
AMPK	activates	gene	0.60
ACHE	inhibits	gene	0.60
ALZHEIMER	activates	gene	0.60
PRESENILIN	activates	gene	0.60
SYNAPSE	contributes_to	gene	0.60
COMPLEMENT	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
RNA	activates	gene	0.60
ALZHEIMER	degrades	gene	0.60
AMYLOID	degrades	gene	0.60
GASDERMIN	degrades	gene	0.60
NEURON	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cortical Layer 5 Pyramidal Neuron GluN2B-Mediated Hyperactiv	0.679	neuroscience	GluN2B-Mediated Thalamocortical Control
Closed-Loop Phase-Specific Targeting of PV-to-Pyramidal Syna	0.585	alzheimers	Closed-loop optogenetic targeting PV int

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PYRAMIDAL in their description or question text

No additional research found