gene 723 words KG: NCOR1 2026-03-24
kind:genesection:genesstate:published
Contents

NCOR1 Gene - Nuclear Receptor Corepressor 1

🧬 Gene Info
Gene SymbolNCOR1
Full NameNuclear Receptor Corepressor 1
AliasesPage for NCOR1 Gene
Chromosome17p12-p11.2
FunctionNCOR1 is a component of several corepressor complexes that regulate gene expression through chromatin remodeling
Primary ExpressionBrain (high), particularly cortex and hippocampus
Amino Acids440 aa
Exons24
PathwaysOxidative Stress, Proteasome
UniProt IDO75376
NCBI Gene ID9612
Ensembl IDENSG00000140989
OMIM607079
GeneCardsNCOR1
Human Protein AtlasNCOR1
Associated DiseasesCancer
InteractionsSIRT1, RNF20, UBIQUITIN, ITGA3, SGK1, BDNF
KG Connections58 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Multi-Modal Stress Response Harmonization
Score: 0.60
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates

Knowledge Graph (12 edges)

NCOR1 activates SIRT1
NCOR1 activates RNF20
NCOR1 activates UBIQUITIN
NCOR1 activates ITGA3
NCOR1 activates SGK1
NCOR1 activates BDNF
NCOR1 regulates Jnk
NCOR1 activates NR4A1
NCOR1 inhibits Jnk
NCOR1 regulates UBIQUITIN