gene 955 words KG: TCF7L2 2026-03-24
kind:genesection:genesstate:published
Contents

TCF7L2 (Transcription Factor 7-Like 2)

🧬 Gene Info
Gene SymbolTCF7L2
AliasesTranscription Factor 7-Like 2
Protein TypeTranscription Factor
FunctionTCF7L2 serves multiple physiological functions
PathwaysWnt, wnt, Wnt signaling, Wnt Signaling
UniProt IDQ9NQB0](https://www.uniprot.org/uniprot/Q9NQB0)
NCBI Gene ID6934
GeneCardsTCF7L2
Human Protein AtlasTCF7L2
Associated DiseasesAls, Diabetes, Type 2 Diabetes, Type 2 Diabetes Mellitus
InteractionsLGALS3, MYC, APOA2, IL1R1, GENES, P53
KG Connections68 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Inhibitory Neuron-Selective WNT Signaling Restoration
Score: 0.39
Noradrenergic-Tau Propagation Blockade
Score: 0.51
APOE-Dependent Autophagy Restoration
Score: 0.61
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.39

Related Analyses (4)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Which cell types show the most significant expression change
neurodegeneration · completed

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: expressed_in
NOX4 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TCF7L2 inhibits LGALS3
TCF7L2 activates MYC
TCF7L2 associated_with HIF1A
TCF7L2 associated_with TFAP4
TCF7L2 interacts_with APOA2
TCF7L2 associated_with SLC30A8
TCF7L2 associated_with MTNR1B
TCF7L2 associated_with Type 2 Diabetes Mellitus
TCF7L2 regulates GLP-1 Receptor
TCF7L2 regulates GIP Receptor