gene 1,077 words KG: ent-gene-d4ef6b3a
Contents

ASAH1 — N-Acylsphingosine Amidohydrolase 1

🧬 Gene Info
Gene SymbolASAH1
Full NameN-Acylsphingosine Amidohydrolase 1
Chromosome8p22
Protein TypeEnzyme
Functionis a lysosomal enzyme that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids.
Molecular Weight~44 kDa (precursor), ~13+20 kDa (processed)
Amino Acids395 aa
Exons16
PathwaysSphingolipid
UniProt ID[Q13510](https://www.uniprot.org/uniprot/Q13510)
Ensembl IDENSG00000104522
OMIM613468
GeneCardsASAH1
Human Protein AtlasASAH1
Associated DiseasesAging, Als, Ms, Parkinson, Parkinson's disease
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Aβ, CERS2, CERS6
KG Connections70 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Sphingolipid Metabolism Reprogramming
Score: 0.62

Related Analyses (2)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (8)

Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
CERS2 — Ceramide Synthase 2 (Lass2)
gene · KG edge: activates
CERS6 Gene
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (2 edges)

ent-gene-d4ef6b3a data_in benchmark_ot_ad_answer_key:ASAH1
benchmark_ot_ad_answer_key:ASAH1 data_in ent-gene-d4ef6b3a

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.