gene

CERS6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CERS6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

0Analyses

50Outgoing

21Incoming

Summary

CERS6 (Ceramide Synthase 6) synthesizes C14- and C16-ceramides and is a key regulator of cellular lipid metabolism. Involved in Alzheimer's disease pathogenesis through amyloid processing and lipid raft dynamics. Also implicated in metabolic disorders and cancer.

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🧬 Gene Info

Gene Symbol	CERS6
Full Name	Ceramide Synthase 6
Chromosome	2q33.3
Protein Type	Synthase
Function	encodes a member of the ceramide synthase family that catalyzes the N-acylation of sphingoid bases to produce ceramides.
Primary Expression	Endoplasmic reticulum membrane, where de novo ceramide synthesis occurs
Subcellular Localization	Endoplasmic reticulum membrane, where de novo ceramide synthesis occurs
Molecular Weight	45 kDa
Amino Acids	384 aa
Pathways	Ceramide Metabolism
UniProt ID	Q3YGD3
NCBI Gene ID	253782
Ensembl ID	ENSG00000166922
OMIM	615990
GeneCards	CERS6
Human Protein Atlas	CERS6
Associated Diseases	neurodegeneration
Interactions	CERS2, APP, PARKIN, ASAH1, SGMS1, SGMS2
KG Connections	81 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CERS6 — AlphaFold Q3YGD3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CERS6["<b>CERS6</b>"]
    Cancer{"Cancer"}
    CERS6 -->|"activates"| Cancer
    CERS6 -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    CERS6 -->|"therapeutic target"| Tumor
    Glioblastoma{"Glioblastoma"}
    CERS6 -->|"therapeutic target"| Glioblastoma
    CANCER["CANCER"]
    CERS6 -->|"activates"| CANCER
    APOPTOSIS["APOPTOSIS"]
    CERS6 -->|"activates"| APOPTOSIS
    WIPI2["WIPI2"]
    CERS6 -->|"expressed in"| WIPI2
    Apoptosis(["Apoptosis"])
    CERS6 -->|"activates"| Apoptosis
    CERS6 -->|"therapeutic target"| CANCER
    CERS6 -->|"therapeutic target"| APOPTOSIS
    CERS2["CERS2"]
    CERS6 -->|"interacts with"| CERS2
    BCL_2["BCL-2"]
    CERS6 -->|"interacts with"| BCL_2
    GBM["GBM"]
    GBM -->|"therapeutic target"| CERS6
    BCL2["BCL2"]
    BCL2 -->|"interacts with"| CERS6
    BCL2L13["BCL2L13"]
    BCL2L13 -->|"interacts with"| CERS6
    style CERS6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (60)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Melanoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Aging	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
WIPI2	expressed_in	gene	0.60
CERS2	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
PARKIN	inhibits	gene	0.60
ASAH1	activates	gene	0.60
CERS2	activates	gene	0.60
SGMS1	activates	gene	0.60
SGMS2	activates	gene	0.60
PINK1	inhibits	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
Apoptosis	activates	pathway	0.60
CANCER	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
BCL-2	interacts_with	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
AGING	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
Mitophagy	interacts_with	pathway	0.60
Immunotherapy	inhibits	pathway	0.60
ALZHEIMER	activates	gene	0.60
Lipid Metabolism	activates	pathway	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
Amyloid	activates	pathway	0.60
Sphingolipid	activates	pathway	0.60
Aβ	activates	protein	0.60
Lipid Metabolism	regulates	pathway	0.60
Macrophage	activates	cell_type	0.60
diabetes	inhibits	disease	0.60
diabetes	activates	disease	0.60
sphingolipid metabolism	participates_in	pathway	0.55

Incoming (21)

Source	Relation	Type	Str
GBM	therapeutic_target	gene	0.60
BCL2	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
SGMS2	activates	gene	0.60
ASAH1	activates	gene	0.60
CERS2	activates	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
AMYLOID	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
FTO	activates	gene	0.60
RNA	activates	gene	0.60
CERS2	co_mentioned	gene	0.55
CERS2	binds_to	gene	0.55
CERS2	associated_with	gene	0.55
CERS2	interacts_with	gene	0.55
AQP4	debate_co_mention	gene	0.45
C1Q	debate_co_mention	gene	0.45
C1QA	debate_co_mention	gene	0.45
CERS2	debate_co_mention	gene	0.45
SGMS2	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CERS6

Understanding Entity Pages

Summary

Wiki Pages (8)

CERS6 Gene

Ceramide Signaling Pathway in Neurodegeneration

Sphingolipid Signaling Pathway in Neurodegeneration

CERS2 Protein (Ceramide Synthase 2)

CERS6 Protein

ceramide-sphingolipid-modulation-therapy