gene 1,156 words KG: CERS6 2026-03-27
kind:genesection:genesstate:published
Contents

CERS6 Gene

🧬 Gene Info
Gene SymbolCERS6
Full NameCeramide Synthase 6
Chromosome2q33.3
Protein TypeSynthase
Functionencodes a member of the ceramide synthase family that catalyzes the N-acylation of sphingoid bases to produce ceramides.
Primary ExpressionEndoplasmic reticulum membrane, where de novo ceramide synthesis occurs
Subcellular LocalizationEndoplasmic reticulum membrane, where de novo ceramide synthesis occurs
Molecular Weight45 kDa
Amino Acids384 aa
PathwaysCeramide Metabolism
UniProt IDQ3YGD3
NCBI Gene ID253782
Ensembl IDENSG00000166922
OMIM615990
GeneCardsCERS6
Human Protein AtlasCERS6
Associated Diseasesneurodegeneration
InteractionsCERS2, APP, PARKIN, ASAH1, SGMS1, SGMS2
KG Connections81 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Sphingolipid Metabolism Reprogramming
Score: 0.44
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Ganglioside Rebalancing Therapy
Score: 0.50
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.47

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.46

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with

Knowledge Graph (12 edges)

CERS6 expressed_in WIPI2
CERS6 interacts_with CERS2
CERS6 interacts_with APP
CERS6 inhibits PARKIN
CERS6 activates ASAH1
CERS6 activates CERS2
CERS6 activates SGMS1
CERS6 activates SGMS2
CERS6 debate_co_mention EPHB4
CERS6 debate_co_mention HSPG2