gene 1,913 words KG: CCR7 2026-03-27
kind:genesection:genesstate:publishedtopic:chemokinetopic:neuroinflammationtopic:alzheimerstopic:stroketopic:immunologyevidence:strong
Contents

CCR7 Gene (C-C Chemokine Receptor Type 7)

🧬 Gene Info
Gene SymbolCCR7
Full NameC-C Chemokine Receptor Type 7
Chromosome15q22.02
Protein FamilyG protein-coupled receptor family
Protein TypeReceptor
FunctionLymph node homing: CCR7 guides mature DCs from peripheral tissues to draining lymph nodes
Amino Acids372 aa
PathwaysPI3K, MAPK
UniProt ID[P36544](https://www.uniprot.org/uniprot/P36544)
Ensembl IDENSG00000126353
GeneCardsCCR7
Human Protein AtlasCCR7
Associated DiseasesAlzheimer's disease, Stroke
Known Drugs/Compoundsnavarixin
InteractionsCCL21
KG Connections16 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: therapeutic_target
slc22a5
gene · KG edge: associated_with
SLC22A4 — Solute Carrier Family 22 Member 4 (OCTN1)
gene · KG edge: associated_with
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: associated_with
OPTN — Optineurin
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

CCR7 therapeutic_target OPTN
CCR7 protects_against OPTN
CCR7 therapeutic_target Autoimmune
CCR7 expressed_in Ms
CCR7 expressed_in Inflammation
CCR7 expressed_in Immune Response
CCR7 activates Rheumatoid Arthritis
CCR7 participates_in ubiquitin-proteasome
OPTN therapeutic_target CCR7
SLC22A4 associated_with CCR7