gene 662 words KG: CDC37 2026-03-22
kind:genesection:genesstate:published
Contents

CDC37

🧬 Gene Info
Gene SymbolCDC37
Protein TypeChaperone
FunctionCDC37 (Cell Division Cycle 37) is an Hsp90 co-chaperone that specifically facilitates the folding and maturation of protein kinases.
Primary Expressionmany cancers
PathwaysChaperone
Ensembl IDENSG00000105401
GeneCardsCDC37
Human Protein AtlasCDC37
Associated DiseasesAls, Cancer, Tumor
InteractionsPINK1, HSP90
KG Connections15 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.50

Related Analyses (2)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (15)

HSP90 Protein (Heat Shock Protein 90)
protein · KG edge: interacts_with
Angiogenesis Pathway
mechanism · KG edge: implicated_in
Packard Center for ALS Research
institution · KG edge: implicated_in
Tumor Necrosis Factor (TNF)
entity · KG edge: implicated_in
PINK1 (PTEN-Induced Kinase 1)
entity · KG edge: interacts_with

Knowledge Graph (12 edges)

CDC37 interacts_with PINK1
CDC37 interacts_with HSP90
CDC37 implicated_in P53
CDC37 implicated_in CANCER
CDC37 implicated_in Tumor
CDC37 implicated_in Cancer
CDC37 implicated_in Als
CDC37 implicated_in Metastasis
CDC37 implicated_in Invasion
CDC37 implicated_in Angiogenesis