protein 888 words KG: HSP90 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

HSP90 Protein (Heat Shock Protein 90)

🔬 Protein Info
Gene SymbolHSP90
AliasesHeat Shock Protein 90
Protein TypeChaperone
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight90 kDa
Amino Acids220 aa
PathwaysApoptosis, Autophagy, Chaperone, Oxidative Stress
GeneCardsHSP90
Human Protein AtlasHSP90
ApproachAgent/Strategy
HSP90 inhibitorsPU-H71
HSP90 activatorsNatural compounds
Co-chaperone modulatorsp23 inhibitors
Associated DiseasesALS, Alzheimer'S Disease, Depression, HUNTINGTON, HUNTINGTON'S
InteractionsTNF, BAX, HSP60, APP, EIF2A, ATG13
KG Connections429 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (23)

HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.42
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
PARP1 Inhibition Therapy
Score: 0.58
Membrane Cholesterol Gradient Modulators
Score: 0.52

Related Analyses (17)

What are the minimal structural requirements for HSP70/HSP90
drug discovery · completed
Do chaperones selectively recognize pathological vs physiolo
protein biochemistry · failed
Do tau-specific HSP90 conformational states exist that diffe
structural biology · failed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (20)

s:** - Compare tau strain spreading in EXT1/EXT2 conditional
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40

See Also (7)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APE2 Gene
gene · KG edge: binds
AKT1 Gene
gene · KG edge: causes

Knowledge Graph (12 edges)

HSP90 expressed_in Schwann Cell
HSP90 co_discussed TAU
HSP90 inhibits TNF
HSP90 therapeutic_target MLKL
HSP90 co_discussed PARP1
HSP90 co_discussed TNF
HSP90 targets MTOR
HSP90 interacts_with GPX4
HSP90 promotes GPX4
HSP90 activates BAX