gene 1,631 words KG: CHN1 2026-03-28
kind:genesection:genesstate:published
Contents

CHN1 — Chimerin 1

🧬 Gene Info
Gene SymbolCHN1
Full NameChimerin 1
AliasesARHGAP2, CHN, NLS1, BCH
Chromosome2q31.1
Protein FamilyRho GTPase-activating proteins (RhoGAPs)
FunctionAlpha-1-chimaerin is expressed predominantly in the nervous system and functions as a critical regulator of Rho GTPase signaling.
Primary ExpressionNeuron-specific, high in brain and peripheral nervous system
UniProt IDP15884
NCBI Gene ID1123
GeneCardsCHN1
Human Protein AtlasCHN1
ProteinAlpha-1-chimaerin
Associated DiseasesAlzheimer, Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases, Parkinson, disease, neurodegeneration
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Mitochondrial Transfer Pathway Enhancement
Score: 0.44

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (7)

Packard Center for ALS Research
institution · KG edge: therapeutic_target
Alzheimer Indonesia
institution · KG edge: associated_with
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: associated_with
MDH1 — Malate Dehydrogenase 1
gene · KG edge: associated_with
Genes
index · KG edge: associated_with

Knowledge Graph (12 edges)

CHN1 associated_with MDH1
CHN1 associated_with RTN1
CHN1 associated_with SNAP25
CHN1 associated_with PI3K
CHN1 associated_with neurodegeneration
CHN1 co_mentioned SNAP25
CHN1 therapeutic_target ALZHEIMER
CHN1 therapeutic_target ALS
CHN1 therapeutic_target PARKINSON
CHN1 therapeutic_target Alzheimer