protein 1,224 words KG: ATG16L1
Contents

ATG16L1 Protein

🔬 Protein Info
Gene SymbolATG16L1
Chromosome2q37.1
Functionis a core autophagy protein essential for autophagosome formation and cellular protein quality control.
Primary Expressionneurons and glial cells throughout the brain, including the cortex, [hippocam
Subcellular Localization</th><td>Autophagosome membrane, Cytoplasm</td></tr>
Amino Acids607 aa
PathwaysAkt, Autophagy, Epigenetic, Mapk, Mtor
Ensembl IDENSG00000085978
GeneCardsATG16L1
Human Protein AtlasATG16L1
Associated DiseasesInflammation, Intestinal Disease, Osteoarthritis, Parkinson, Rheumatoid Arthritis, Tumor
Known Drugs/Compoundsrapamycin
InteractionsRB1CC1, GABARAP, ERN1, STAT3, IFNG, LC3
KG Connections568 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Autophagosome Maturation Checkpoint Control
Score: 0.49
HDAC3-Selective Inhibition for Clock Reset
Score: 0.46
Lysosomal Positioning Dynamics Modulation
Score: 0.43

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (8)

Alzheimer Indonesia
institution · KG edge: inhibits
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: activates
AMPD2 — Adenosine Monophosphate Deaminase 2
gene · KG edge: expressed_in
AMBRA1 Gene
gene · KG edge: activates
AKT1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

ATG16L1 interacts_with RB1CC1
ATG16L1 interacts_with GABARAP
ATG16L1 interacts_with ERN1
ATG16L1 interacts_with STAT3
ATG16L1 interacts_with IFNG
ATG16L1 interacts_with LC3
ATG16L1 interacts_with RPTOR
ATG16L1 interacts_with RB1
ATG16L1 interacts_with EIF2AK3
ATG16L1 interacts_with RIPK1