gene 786 words KG: COX15 2026-03-22
kind:genesection:genesstate:published
Contents

COX15 — Cytochrome C Oxidase Assembly Factor 15

🧬 Gene Info
Gene SymbolCOX15
Full NameCytochrome C Oxidase Assembly Factor 15
Chromosome10q24.2
FunctionCOX15 plays a crucial role in the final steps of heme A synthesis
Primary Expressionall tissues with high energy demands: - Heart and skeletal muscle (highest expression) - Brain (neurons and glia) - Liver and kid
Molecular Weight42 kDa
UniProt ID[Q7B433](https://www.uniprot.org/uniprot/Q7B433)
Ensembl IDENSG00000074981
OMIM603646
GeneCardsCOX15
Human Protein AtlasCOX15
Associated Diseasesneurodegeneration
InteractionsCOX4I1, COX7A1, COX8A, NDUFA12, NDUFA5, NDUFS1
KG Connections21 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (1)

Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51

Related Analyses (2)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (9)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: activates
VPS33A Gene
gene · KG edge: associated_with
VPS16 Gene
gene · KG edge: associated_with
RPL4 — Ribosomal Protein L4
gene · KG edge: associated_with
PPP1R7 — SDS22 (Protein Phosphatase 1 Regulatory Subuni
gene · KG edge: associated_with

Knowledge Graph (12 edges)

COX15 associated_with RPL4
COX15 inhibits COX4I1
COX15 inhibits COX7A1
COX15 inhibits COX8A
COX15 inhibits NDUFA12
COX15 inhibits NDUFA5
COX15 inhibits NDUFS1
COX15 inhibits NDUFS4
COX15 involved_in OXPHOS
COX15 activates ATP