gene 918 words KG: VPS16 2026-03-21
kind:genesection:genesstate:published
Contents

VPS16 Gene

🧬 Gene Info
Gene SymbolVPS16
Full NameVacuolar Protein Sorting 16 Homolog
Chromosome20q13.33
FunctionIn neurons, VPS16 and the HOPS complex play essential roles in
Molecular Weight89 kDa
Amino Acids790 aa
UniProt IDQ9H269
NCBI Gene ID64601
Ensembl IDENSG00000112357
OMIM614464
GeneCardsVPS16
Human Protein AtlasVPS16
Core Complex ContextHOPS/CORVET-class tethering machinery
Associated Diseasescolorectal cancer, dystonia
InteractionsLC3, VPS33A, UVRAG, STX17, AND, LYSOSOME
KG Connections26 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Autophagosome Maturation Checkpoint Control
Score: 0.49
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: activates
Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: participates_in
Packard Center for ALS Research
institution · KG edge: interacts_with
VPS33A Gene
gene · KG edge: inhibits
UVRAG Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

VPS16 inhibits LC3
VPS16 component_of HOPS
VPS16 causes dystonia
VPS16 associated_with colorectal cancer
VPS16 component_of CORVET
VPS16 participates_in endosome
VPS16 inhibits VPS33A
VPS16 interacts_with UVRAG
VPS16 inhibits STX17
VPS16 associated_with COX15