gene 1,225 words KG: PEX3 2026-03-24
kind:genesection:genesstate:published
Contents

PEX3 Gene - Peroxisome Biogenesis Factor 3

🧬 Gene Info
Gene SymbolPEX3
Full NamePeroxisome Biogenesis Factor 3
AliasesPage for PEX3 Gene, Page for PEX3 Protein
Functionis a 476-amino acid peroxisomal membrane protein that plays a central role in peroxisome biogenesis.
Molecular Weight52 kDa
Amino Acids476 aa
PathwaysMAPK signaling, Reactive Oxygen Species, apoptosis, apoptosis pathway, autophagy pathway
Ensembl IDENSG00000034693
GeneCardsPEX3
Human Protein AtlasPEX3
Associated DiseasesAD, ALI, ALS, Alzheimer, Parkinson
InteractionsSQSTM1, BCL2, LMNA, STING1, TAX1BP1, ATM
KG Connections471 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

PEX3 activates PINK1
PEX3 activates PRKN
PEX3 activates PTEN
PEX3 activates RB1CC1
PEX3 activates RHOT1
PEX3 activates RIPK3
PEX3 activates RTN3
PEX3 activates SESN2
PEX3 activates SNCA
PEX3 activates SNCAIP