gene

NDUFA12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFA12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

11Outgoing

14Incoming

0Experiments

0Debates

Summary

NDUFA12 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with Als, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NDUFA12
Chromosome	12q14.2
Protein Type	Gene
Function	is a nuclear-encoded mitochondrial gene that encodes an accessory subunit of NADH:ubiquinone oxidoreductase, also known as Complex I of the mitochondrial respiratory chain[@giant2015][@atomic2016].
Amino Acids	172 aa
UniProt ID	Q9P0J7
NCBI Gene ID	4706
Ensembl ID	ENSG00000184752
OMIM	614225
GeneCards	NDUFA12
Human Protein Atlas	NDUFA12
Associated Diseases	neurodegeneration
Interactions	COX15, COX4I1, COX7A1, COX8A, NDUFA5, NDUFS1
KG Connections	25 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NDUFA12 — AlphaFold Q9P0J7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NDUFA12 Gene

gene · 2177 words

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Pathway Diagram

graph TD
    NDUFA12["<b>NDUFA12</b>"]
    Als{"Als"}
    NDUFA12 -->|"regulates"| Als
    Ms{"Ms"}
    NDUFA12 -->|"regulates"| Ms
    YWHAH["YWHAH"]
    NDUFA12 -->|"associated with"| YWHAH
    NDUFS5["NDUFS5"]
    NDUFA12 -->|"associated with"| NDUFS5
    neurodegeneration["neurodegeneration"]
    NDUFA12 -->|"implicated in"| neurodegeneration
    NDUFA2["NDUFA2"]
    NDUFA2 -->|"associated with"| NDUFA12
    NDUFS6["NDUFS6"]
    NDUFS6 -->|"associated with"| NDUFA12
    NDUFA1["NDUFA1"]
    NDUFA1 -->|"associated with"| NDUFA12
    CBL["CBL"]
    CBL -->|"associated with"| NDUFA12
    PDGFRB["PDGFRB"]
    PDGFRB -->|"associated with"| NDUFA12
    HSP90AB1["HSP90AB1"]
    HSP90AB1 -->|"associated with"| NDUFA12
    CRKL["CRKL"]
    CRKL -->|"associated with"| NDUFA12
    DOCK1["DOCK1"]
    DOCK1 -->|"associated with"| NDUFA12
    style NDUFA12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
OXPHOS	involved_in	pathway	0.90
Oxidative Phosphorylation	involved_in	pathway	0.90
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
NDUFA5	inhibits	gene	0.60
NDUFS1	inhibits	gene	0.60
NDUFS4	inhibits	gene	0.60
YWHAH	associated_with	gene	0.60
NDUFS5	associated_with	gene	0.60
NDUFA5	co_expressed_with	gene	0.50
NDUFS1	co_expressed_with	gene	0.50

Incoming (14)

Source	Relation	Type	Str
COX8A	inhibits	gene	0.60
NDUFS6	associated_with	gene	0.60
NDUFA1	associated_with	gene	0.60
CBL	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
HSP90AB1	associated_with	gene	0.60
CRKL	associated_with	gene	0.60
DOCK1	associated_with	gene	0.60
COX7A1	inhibits	gene	0.60
NDUFA2	associated_with	gene	0.60
COX15	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
COX7A1	co_expressed_with	gene	0.50
COX8A	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity