Contents

EEF2K — Eukaryotic Elongation Factor 2 Kinase

🧬 Gene Info

Gene Symbol	EEF2K
Full Name	Eukaryotic Elongation Factor 2 Kinase
Chromosome	16p13.3
Protein Type	Kinase
Function	is a unique calcium/calmodulin-dependent kinase that regulates protein synthesis by phosphorylating eukaryotic elongation factor 2 (eEF2).
Primary Expression	human tissues, with particular importance in the brain where it regulates translation elongation in response to cellular signals
Subcellular Localization	both the cell body and dendritic compartments, where it regulates local translation in response to synaptic activity
Amino Acids	724 aa
Pathways	AMPK, mTOR, MAPK Pathway
Ensembl ID	ENSG00000103319
GeneCards	EEF2K
Human Protein Atlas	EEF2K
Calcium/Calmodulin Binding	Primary activation mechanism
AMP-Activated Protein Kinase (AMPK)	Phosphorylates and activates EEF2K during energy stress
mTORC1 Signaling	Inhibits EEF2K through S6K-mediated phosphorylation
Associated Diseases	neurodegeneration
Interactions	AND, AUTOPHAGY, BDNF, CANCER, CYTOKINES, DEPRESSION
KG Connections	22 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph