| Gene Symbol | EEF2K |
| Full Name | Eukaryotic Elongation Factor 2 Kinase |
| Chromosome | 16p13.3 |
| Protein Type | Kinase |
| Function | is a unique calcium/calmodulin-dependent kinase that regulates protein synthesis by phosphorylating eukaryotic elongation factor 2 (eEF2). |
| Primary Expression | human tissues, with particular importance in the brain where it regulates translation elongation in response to cellular signals |
| Subcellular Localization | both the cell body and dendritic compartments, where it regulates local translation in response to synaptic activity |
| Amino Acids | 724 aa |
| Pathways | AMPK, mTOR, MAPK Pathway |
| Ensembl ID | ENSG00000103319 |
| GeneCards | EEF2K |
| Human Protein Atlas | EEF2K |
| Calcium/Calmodulin Binding | Primary activation mechanism |
| AMP-Activated Protein Kinase (AMPK) | Phosphorylates and activates EEF2K during energy stress |
| mTORC1 Signaling | Inhibits EEF2K through S6K-mediated phosphorylation |
| Associated Diseases | neurodegeneration |
| Interactions | AND, AUTOPHAGY, BDNF, CANCER, CYTOKINES, DEPRESSION |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!