gene 817 words KG: FOXO6 2026-03-21
kind:genesection:genesstate:published
Contents

FOXO6 Gene

🧬 Gene Info
Gene SymbolFOXO6
Chromosome1p33
Protein TypeTranscription Factor
FunctionSynaptic plasticity: BDNF, ARC, EGR1 immediate early genes
Amino Acids524 aa
Exons3
Ensembl IDENSG00000204060
GeneCardsFOXO6
Human Protein AtlasFOXO6
Forkhead DNA-binding domainWinged-helix structure for DNA recognition
Nuclear localization signalRegulates subcellular distribution
Transactivation domainInteracts with co-activators
Spatial memoryRequired for Morris water maze performance
Contextual fear conditioningRegulates memory consolidation
Synaptic plasticityModulates long-term potentiation (LTP)
Associated DiseasesAls
InteractionsCANCER
KG Connections67 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: contributes_to
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: contributes_to
Packard Center for ALS Research
institution · KG edge: associated_with
FOXO4 — Forkhead Box O4
gene · KG edge: associated_with
FOXO3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FOXO6 associated_with FOXO3
FOXO6 associated_with FOXP3
FOXO6 associated_with FOXG1
FOXO6 expressed_in SHH
FOXO6 associated_with FOXP1
FOXO6 associated_with FOXM1
FOXO6 associated_with FOXP4
FOXO6 associated_with FOXO4
FOXO6 associated_with FOXO1
FOXO6 associated_with FOXP2