gene 3,329 words KG: FOXO4
Contents

FOXO4 — Forkhead Box O4

🧬 Gene Info
Gene SymbolFOXO4
Full NameForkhead Box O4
ChromosomeXq13.1
Protein FamilyForkhead box O family
Protein TypeTranscription Factor
Functionis a transcription factor belonging to the FOX O subfamily of Forkhead box proteins.
Primary Expressionvarious tissues with particularly high levels in:
Molecular Weight59.6 kDa
Amino Acids556 aa
Exons4
Gene TypeTranscription factor
PathwaysPI3K
UniProt IDP98177
NCBI Gene ID8941
Ensembl IDENSG00000124780
OMIM300434
GeneCardsFOXO4
Human Protein AtlasFOXO4
Associated DiseasesAls
InteractionsUBIQUITIN, AKT, Rb, LYSOSOME, AMPK, AUTOPHAGY
KG Connections78 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

FOXO Signaling Pathway in Neurodegeneration
mechanism · KG edge: contributes_to
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: contributes_to
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: contributes_to
Packard Center for ALS Research
institution · KG edge: associated_with
FOXO3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FOXO4 associated_with FOXO1
FOXO4 associated_with FOXP2
FOXO4 activates UBIQUITIN
FOXO4 contributes_to FOXO1
FOXO4 associated_with FOXP1
FOXO4 expressed_in SHH
FOXO4 associated_with FOXO3
FOXO4 associated_with FOXA2
FOXO4 associated_with FOXP4
FOXO4 associated_with FOXG1