gene 1,234 words KG: FOXM1 2026-03-24
kind:genesection:genesstate:published
Contents

FOXM1 Gene

🧬 Gene Info
Gene SymbolFOXM1
Chromosome12p13.33
Protein TypeTranscription Factor
FunctionFOXM1 is a key transcriptional regulator of cell cycle and DNA repair genes[@koo2012]:
Molecular Weight82 kDa
Amino Acids664 aa
PathwaysChemoresistance, Complement, Epigenetic, Hedgehog, Nf-Κb
GeneCardsFOXM1
Human Protein AtlasFOXM1
Tissue/Cell TypeExpression Level
Developing brainHigh
Neural stem cellsHigh
Embryonic neuronsModerate
Adult brainLow
Adult neuronsVery low
Associated DiseasesCancer, Carcinoma, Lung Cancer, Melanoma, Tumor
InteractionsRHOT1, AUTOPHAGY, CANCER, AND, APOPTOSIS, FOXO3
KG Connections179 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (4)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: regulates
CD44 - Cell Surface Glycoprotein
gene · KG edge: therapeutic_target
BRG1 Gene
gene · KG edge: regulates
BAG3 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

FOXM1 therapeutic_target LEF1
FOXM1 regulates SMARCA4
FOXM1 therapeutic_target TERT
FOXM1 therapeutic_target FZD7
FOXM1 therapeutic_target JAG1
FOXM1 therapeutic_target MITF
FOXM1 therapeutic_target GAIN
FOXM1 regulates AXIN2
FOXM1 therapeutic_target CD44
FOXM1 therapeutic_target ALDH1A1