| Gene Symbol | HERC6 |
| Full Name | HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 6 |
| Chromosome | 12p13.31 |
| Protein Family | HERC family (HECT and RLD domain containing) |
| Protein Type | Ligase |
| Function | is a large E3 ubiquitin ligase that plays critical roles in antiviral immunity, protein quality control, and cellular stress responses [1][2]. |
| Primary Expression | Ubiquitous, high in immune tissues |
| Subcellular Localization | , including association with membranes and organelles |
| Molecular Weight | ~470 kDa |
| Amino Acids | 258 aa |
| Pathways | mTOR signaling |
| UniProt ID | Q8IWV1 |
| NCBI Gene ID | 55076 |
| Ensembl ID | ENSG00000138650 |
| OMIM | 611236 |
| GeneCards | HERC6 |
| Human Protein Atlas | HERC6 |
| Associated Diseases | neurodegeneration |
| Interactions | IFN |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsHPASTRING |