concept

ISG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ISG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ISG
Key Genes/Proteins	IFNG
Related Diseases	Als, Ms, Ischemia, Infection, Viral Infection
Related Pathways	Complement

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ISG["ISG"]
    ISG -->|"activates"| Als["Als"]
    ISG -->|"activates"| Complement["Complement"]
    ISG -->|"activates"| Ms["Ms"]
    ISG -->|"activates"| Ischemia["Ischemia"]
    ISG -->|"activates"| Infection["Infection"]
    ISG -->|"activates"| Viral_Infection["Viral Infection"]
    ISG -->|"activates"| Neuroinflammation["Neuroinflammation"]
    ISG -->|"activates"| Inflammation["Inflammation"]
    TYPE_I_IFN["TYPE_I_IFN"] -->|"activates"| ISG
    VIRAL_INFECTIONS["VIRAL INFECTIONS"] -->|"activates"| ISG
    TLR3["TLR3"] -->|"activates"| ISG
    CYTOKINES["CYTOKINES"] -->|"activates"| ISG
    FAS["FAS"] -->|"activates"| ISG
    MICROGLIA["MICROGLIA"] -->|"activates"| ISG
    UBIQUITIN["UBIQUITIN"] -->|"activates"| ISG
    COMPLEMENT["COMPLEMENT"] -->|"activates"| ISG

Outgoing (68)

Target	Relation	Type	Str
Als	activates	disease	0.75
Complement	activates	pathway	0.70
microglia	expressed_in	cell_type	0.70
Ms	activates	disease	0.65
Ischemia	activates	disease	0.65
Infection	activates	disease	0.65
Viral Infection	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Stroke	activates	disease	0.65
Parkinson	activates	disease	0.65
ALS	activates	disease	0.65
CXCL10	expressed_in	gene	0.60
Toll-Like Receptor	activates	pathway	0.60
Innate Immunity	activates	pathway	0.60
TNF	activates	gene	0.60
RIPK1	activates	gene	0.60
ZBP1	activates	gene	0.60
RIPK3	activates	gene	0.60
FADD	activates	gene	0.60
Necroptosis	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
COMPLEMENT	activates	gene	0.60
IFN	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	activates	gene	0.60
MICROGLIA	expressed_in	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
SYNAPSE	activates	gene	0.60
DNA	activates	gene	0.60
Microglia	expressed_in	cell_type	0.60
Apoptosis	activates	pathway	0.60
PARKINSON	activates	gene	0.60
LRRK2	expressed_in	gene	0.60
Oxidative Stress	activates	pathway	0.60
Macrophage	activates	cell_type	0.60
Microglia	inhibits	cell_type	0.60
AND	activates	gene	0.60
Neuroinflammatory	activates	pathway	0.60
Amyloid	activates	pathway	0.60
TNFR1	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
MICROGLIA	inhibits	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60

Incoming (33)

Source	Relation	Type	Str
IFNG	upregulates	gene	0.95
TYPE_I_IFN	activates	protein	0.64
VIRAL INFECTIONS	activates	gene	0.60
TLR3	activates	gene	0.60
CYTOKINES	activates	gene	0.60
FAS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
AND	activates	gene	0.60
RIPK1	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
IFN	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
RIPK3	activates	gene	0.60
TNF	activates	gene	0.60
TNFR1	activates	gene	0.60
NRF2	activates	gene	0.60
STROKE	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
DNA	activates	gene	0.60
IFN	expressed_in	gene	0.60
MICROGLIA	inhibits	gene	0.60
SYNAPSE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
LRRK2	expressed_in	gene	0.60
CGAS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MICROGLIA	expressed_in	gene	0.60
PARKINSON	activates	gene	0.60
HERC6	degrades	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ISG

Understanding Entity Pages

Wiki Pages (20)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

nlrc5-protein

cGAS-STING Signaling in Parkinson's Disease

IL28B (Interleukin 28B)

cGAS-STING Pathway Dysregulation Hypothesis in Parkinson's Disease

Interferon Signaling in Neurodegeneration

CBS Microglial Neuroimmune Axis

IL27 — Interleukin 27

cGAS-STING Pathway in Neurodegeneration

herc5

cGAS-STING Inhibitors for Parkinson's Disease

HERC6 — HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 6

IL28A (Interleukin-28A)

NRTI Immunomodulation in Alzheimer's Disease: Molecular Mechanisms and Therapeutic Potential

NLRC5 — NLR Family CARD Domain Containing 5

DNAJC20 Gene

cGAS-STING Pathway in Alzheimer's Disease

CGAS Gene