| Gene Symbol | HERC5 |
| Protein Type | Ligase |
| Function | ISG15 is a 165-amino acid ubiquitin-like protein that can be covalently attached to lysine residues on substrate proteins. |
| Subcellular Localization | HERC5 is primarily localized to the: |
| Amino Acids | 693 aa |
| Exons | 22 |
| Pathways | Apoptosis, Immune Response, Innate Immunity, Mtor, Nf-Κb |
| Ensembl ID | ENSG00000138617 |
| GeneCards | HERC5 |
| Human Protein Atlas | HERC5 |
| N-terminal RCC1-like domain (RLD) | Contains multiple RCC1 repeats that function as guanine nucleotide exchange factors for small GTPases |
| HECT domain | The catalytic E3 ubiquitin ligase domain at the C-terminus (~350 amino acids) |
| Multiple WD40 repeats | Involved in protein-protein interactions |
| Flexible linker regions | Connect the various domains |
| Cytoplasm | Major site of ISG15 conjugation activity |
| Associated Diseases | neurodegeneration |
| Interactions | MAVS, MUL1, UBIQUITIN, DRP1, AUTOPHAGY, Ras |
| KG Connections | 79 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |