gene 611 words KG: IL16 2026-03-21
kind:genesection:genesstate:published
Contents

IL16 Gene

🧬 Gene Info
Gene SymbolIL16
Chromosome15q22.3
FunctionIL-16 has diverse biological functions:
Primary Expressionneurons, astrocytes, and microglia, where it modulates inflamm
Molecular Weight~14 kDa (mature form)
Amino Acids631 aa
PathwaysMAPK, PI3K, NF-κB
NCBI Gene ID3603
GeneCardsIL16
Human Protein AtlasIL16
Protein ClassCytokine
Cell TypeExpression Level
NeuronsModerate
AstrocytesHigh
MicrogliaHigh
Associated DiseasesAls, Inflammation, Ms, Traumatic Brain Injury
KG Connections49 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Tau Protein
protein · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: therapeutic_target
MDH1 — Malate Dehydrogenase 1
gene · KG edge: associated_with
FMN2 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

IL16 biomarker_for GFAP
IL16 associated_with TAU
IL16 associated_with MDH1
IL16 associated_with IL1B
IL16 expressed_in Autism
IL16 expressed_in Dna Methylation
IL16 associated_with Inflammation
IL16 associated_with Traumatic Brain Injury
IL16 associated_with Als
IL16 associated_with Ms