gene 1,278 words KG: S100B 2026-03-24
kind:genesection:genesstate:published
Contents

S100B Gene

🧬 Gene Info
Gene SymbolS100B
Full NameS100 Calcium Binding Protein B
Chromosome21q22.3
Protein FamilyS100 EF-hand calcium binding proteins
Functionis a gene encoding a calcium-binding protein of the S100 family, playing crucial roles in neuronal function, astrocyte biology, and neuroinflammation.
Molecular Weight10.5 kDa
Amino Acids92 aa
PathwaysPI3K
UniProt ID[P16401](https://www.uniprot.org/uniprot/P16401)
Ensembl IDENSG00000122574
OMIM176990
GeneCardsS100B
Human Protein AtlasS100B
Associated DiseasesAls, Cardiovascular, Glioma, Inflammation, Ms, Neurodegeneration
InteractionsC1Q, TGM2, GPNMB, HMGB1, APP, GFAP
KG Connections366 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Astrocyte-Mediated Microglial Memory Erasure
Score: 0.46
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Glial Glycocalyx Remodeling Therapy
Score: 0.41
Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.49
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: biomarker_for
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: biomarker_for
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
BDNF Gene
gene · KG edge: activates
AQP4 (Aquaporin-4 Gene)
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

S100B provides_data_for ds-f2c28aed24a7
S100B biomarker_for PLAU
S100B biomarker_for CXCL10
S100B activates C1Q
S100B biomarker_for CX3CL1
S100B biomarker_for VIM
S100B biomarker_for BDNF
S100B activates TGM2
S100B activates GPNMB
S100B activates HMGB1