gene 606 words KG: CALCOCO2 2026-03-21
kind:genesection:genesstate:published
Contents

CALCOCO2 — Calcium Binding and Coiled-Coil Domain 2

🧬 Gene Info
Gene SymbolCALCOCO2
Full NameCalcium Binding and Coiled-Coil Domain 2
Chromosome17q25.1
Protein TypeReceptor
FunctionXenophagy: Recognition and elimination of intracellular pathogens including bacteria, viruses, and parasites
Molecular Weight52 kDa
Amino Acids446 aa
PathwaysAkt, Autophagy, Mapk, Mitophagy, Mtor
UniProt ID[Q9BQB6](https://www.uniprot.org/uniprot/Q9BQB6)
Ensembl IDENSG00000136436
OMIM604551
GeneCardsCALCOCO2
Human Protein AtlasCALCOCO2
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Cardiac, Crohn's disease
Known Drugs/Compoundsdimethyl fumarate, rapamycin
InteractionsLC3, BECN1, C9ORF72, NBR1, G3BP1, TOLLIP
KG Connections1130 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (21)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.42
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (13)

What determines the spatial organization of autophagy recept
neurodegeneration · failed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (3)

Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90
Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
AMBRA1 Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: regulates
ACTB Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CALCOCO2 activates G3BP1
CALCOCO2 activates P62
CALCOCO2 activates SQSTM1
CALCOCO2 expressed_in SQSTM1
CALCOCO2 activates FUS
CALCOCO2 activates NBR1
CALCOCO2 activates OPTINEURIN
CALCOCO2 activates OPTN
CALCOCO2 activates SMCR8
CALCOCO2 activates TAX1BP1