| Gene Symbol | TAU |
| Chromosome | 17q21.31 |
| Protein Family | MAPT family |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neurons, where they bind to microtubules and promote their polymerization and stability |
| Subcellular Localization | Axons, Neurons |
| Molecular Weight | 45-65 kDa (isoform dependent) |
| Amino Acids | 441 aa |
| Pathways | Extracellular Aggregation, Hyperphosphorylation, Neurofibrillary Tangle Formation, Protein Assembly, Synapse Pathology |
| GeneCards | TAU |
| Human Protein Atlas | TAU |
| Gene [@ballatore2007]
MAPT [@avila2004]
[@spiresjones2014]
[@schmitt2021]
UniProt ID [@huang2023]
P10636 [@jin2011]
PDB IDs | 4NP6, 5O3L, 6HVM |
| Associated Diseases | AD, ALS, ALZHEIMER'S DISEASE, ALZHEIMERS_DISEASE, AMYLOID PLAQUES, AXONAL TRANSPORT |
| Known Drugs/Compounds | METFORMIN, MELATONIN, Monoclonal Antibodies, Rutin, Flavonoids, Hyperbaric Oxygen Therapy |
| Interactions | PP2A, KEAP1, NRF2, CDK5, LC3, MAPT |
| KG Connections | 5378 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |