gene 2,879 words KG: CD33
Contents

CD33 — Cluster of Differentiation 33

🧬 Gene Info
Gene SymbolCD33
Full NameCluster of Differentiation 33
AliasesSiglec-3
Chromosome19q13.41
FunctionSialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins
Molecular Weight67 kDa
Amino Acids354 aa
Exons7
Gene TypeProtein coding
PathwaysApoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic
UniProt IDP07846
NCBI Gene ID945
Ensembl IDENSG00000141548
OMIM159590
GeneCardsCD33
Human Protein AtlasCD33
Associated DiseasesALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, Aging
Known Drugs/CompoundsStem Cell Therapy
InteractionsOVERVIEW, PSEN1, BCL2, APP, DAP12, APOE
KG Connections708 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.41
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42

Related Analyses (10)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
adam17
gene · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

CD33 mediates TREM2
CD33 mediates TYROBP
CD33 associated_with CR1
CD33 associated_with CTSB
CD33 associated_with CTSH
CD33 associated_with EED
CD33 associated_with GRN
CD33 associated_with INPP5D
CD33 associated_with LILRB2
CD33 associated_with PICALM