gene 654 words KG: BRCA2 2026-03-22
kind:genesection:genesstate:published
Contents

BRCA2 Gene

🧬 Gene Info
Gene SymbolBRCA2
Full NameBRCA2 DNA Repair Associated
Chromosome13q13.1
FunctionThe BRCA2 gene encodes BRCA2 DNA Repair Associated, involved in DNA repair and genomic stability
Molecular Weight384 kDa
PathwaysAutophagy, Ferroptosis, Homologous Recombination, Innate Immunity, Oxidative Stress
UniProt IDP51587
NCBI Gene ID675
Ensembl IDENSG00000139618
OMIM600185
GeneCardsBRCA2
Human Protein AtlasBRCA2
Associated DiseasesAls, Breast Cancer, Cancer, Carcinoma
InteractionsATM, HMGCR, BRCA1, PARP1, FERROPTOSIS, CANCER
KG Connections166 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.40

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: associated_with
BRCA1 Gene
gene · KG edge: activates
BICD2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

BRCA2 activates Homologous Recombination
BRCA2 inhibits ATM
BRCA2 biomarker_for RANK
BRCA2 expressed_in ATM
BRCA2 biomarker_for RB1
BRCA2 expressed_in CDK12
BRCA2 biomarker_for AKT
BRCA2 associated_with ATM
BRCA2 associated_with STK11
BRCA2 associated_with BRIP1