gene 1,597 words KG: NR1D2 2026-03-27
kind:genesection:genestopic:parkinsonstopic:alzheimers
Contents

NR1D2 (Nuclear Receptor Subfamily 1 Group D Member 2)

🧬 Gene Info
Gene SymbolNR1D2
AliasesREV-ERBβ
Chromosome3p24.2.
Protein TypeReceptor
Functionis a nuclear receptor protein that functions as a transcriptional repressor and plays a critical role in the molecular circadian clock[@partch2014].
Molecular Weight51 kDa
Amino Acids478 aa
Ensembl IDENSG00000150051
GeneCardsNR1D2
Human Protein AtlasNR1D2
Associated DiseasesParkinson's disease, Alzheimer's disease
KG Connections9 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (4)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (2)

REV-ERB pharmacological activation blocks SD effects
validation · proposed · Score: 0.90
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: expressed_in
TGM2 — Transglutaminase 2
gene · KG edge: expressed_in
RORA — RAR Related Orphan Receptor A
gene · KG edge: associated_with
PIK3R1 Gene
gene · KG edge: expressed_in
Lysosomal Associated Membrane Protein 3 (LAMP3)
gene · KG edge: expressed_in

Knowledge Graph (9 edges)

NR1D2 associated_with CKAP4
NR1D2 expressed_in GAIN
NR1D2 expressed_in LAMP3
NR1D2 expressed_in ABCG1
NR1D2 associated_with RORA
NR1D2 expressed_in TGM2
NR1D2 expressed_in PIK3R1
NR1D2 expressed_in WTAP
NR1D2 expressed_in Als