| Gene Symbol | RORA |
| Full Name | RAR Related Orphan Receptor A |
| Protein Type | Receptor |
| Function | is a member of the nuclear receptor superfamily that functions as a transcriptional activator in the circadian clock machinery. |
| Primary Expression | Prefrontal Cortex, Cortex |
| Pathways | Autophagy, Notch, Metastasis, Chemoresistance, Apoptosis |
| GeneCards | RORA |
| Human Protein Atlas | RORA |
| N-terminal activation domain (AF-1) | Responsible for transcriptional activation and protein-protein interactions |
| DNA-binding domain (DBD) | Contains two zinc-finger motifs that recognize specific DNA sequences |
| Hinge region | Provides flexibility and contains the ligand-binding domain |
| Ligand-binding domain (LBD) | Contains the AF-2 activation function and mediates interactions with co-regulators |
| Associated Diseases | Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes |
| Interactions | SQSTM1, LC3, FGF14, GRIN2A, NLGN1, KCNIP4 |
| KG Connections | 124 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |