gene 1,174 words KG: CKAP4 2026-03-29
kind:genesection:genesstate:published
Contents

CKAP4 — Cytoskeleton-Associated Protein 4

🧬 Gene Info
Gene SymbolCKAP4
Full NameCytoskeleton-Associated Protein 4
Chromosome12p13.1
Functionis a type II transmembrane protein localized to the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and nuclear envelope.
Primary Expressionthe brain, particularly in motor neurons of the spinal cord and motor cortex
Subcellular Localizationthe endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and nuclear envelope. The protein plays criti
Molecular Weight63 kDa
Amino Acids400 aa
PathwaysWnt signaling
UniProt IDQ07011
NCBI Gene ID10527
Ensembl IDENSG00000129195
OMIM616404
GeneCardsCKAP4
Human Protein AtlasCKAP4
Associated DiseasesAlzheimer's Disease, Cancer
InteractionsRANBP2, NBR1, AKT, Rb, ADAM15, MMP9
KG Connections49 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

ER Stress and Unfolded Protein Response in Corticobasal
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: expressed_in
Lysosomal Associated Membrane Protein 3 (LAMP3)
gene · KG edge: expressed_in
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: expressed_in
FAM134B — Family With Sequence Similarity 134 Member B
gene · KG edge: regulates

Knowledge Graph (12 edges)

CKAP4 activates RANBP2
CKAP4 activates NBR1
CKAP4 activates AKT
CKAP4 regulates FAM134B
CKAP4 activates Rb
CKAP4 activates ADAM15
CKAP4 activates MMP9
CKAP4 inhibits PI3K
CKAP4 expressed_in GAIN
CKAP4 expressed_in LAMP3