| Gene Symbol | LMX1A |
| Full Name | LIM Homeobox Transcription Factor 1 Alpha |
| Chromosome | 1q22 |
| Protein Type | Transcription Factor |
| Function | It regulates gene expression through binding to specific DNA sequences and recruiting transcriptional co-activators or co-repressors. |
| Primary Expression | substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) dopaminergic neurons |
| Pathways | WNT signaling, WNT |
| UniProt ID | Q8WWI6 |
| NCBI Gene ID | 26118 |
| Ensembl ID | ENSG00000187123 |
| GeneCards | LMX1A |
| Human Protein Atlas | LMX1A |
| Tyrosine hydroxylase (TH) | rate-limiting enzyme in dopamine synthesis |
| Dopamine transporter (DAT/SLC6A3) | regulates dopamine reuptake |
| VMAT2 (SLC18A2) | vesicular dopamine transporter |
| Associated Diseases | neurodegeneration |
| Interactions | ascl1, ASCL1, Bdnf, BDNF, DAT, EN1 |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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