gene 1,761 words KG: ASCL1 2026-03-28
kind:genesection:genesstate:published
Contents

ASCL1 Gene

🧬 Gene Info
Gene SymbolASCL1
Full NameAchaete-Scute Homolog 1
Chromosome12p23.2
Protein TypeTranscription Factor
Functionis a basic helix-loop-helix (bHLH) transcription factor essential for neural development, neurogenesis, and the differentiation of specific neuronal lineages.
Primary Expressionmultiple developmental contexts:
Molecular Weight26.8 kDa
Amino Acids237 aa
UniProt IDP50567
NCBI Gene ID41
Ensembl IDENSG00000139352
OMIM100800
GeneCardsASCL1
Human Protein AtlasASCL1
Encoded ProteinbHLH transcription factor
Associated DiseasesCancer, Lung Cancer, Tumor
InteractionsBCL2, KDM6A, NEUROD1, GDNF, BDNF, LMX1A
KG Connections118 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Quantum Coherence Disruption in Cellular Communication
Score: 0.34
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48

Related Analyses (7)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (7)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
BDNF Gene
gene · KG edge: activates
BCL2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

ASCL1 regulates SEZ6
ASCL1 associated_with DLX2
ASCL1 activates BCL2
ASCL1 activates KDM6A
ASCL1 activates NEUROD1
ASCL1 activates GDNF
ASCL1 activates BDNF
ASCL1 activates LMX1A
ASCL1 activates NURR1
ASCL1 activates PRKN