| Gene Symbol | GDNF |
| Full Name | Glial Cell Line-Derived Neurotrophic Factor |
| Protein Family | GDNF family (TGF-β superfamily) |
| Function | Maintains tyrosine hydroxylase expression |
| Primary Expression | Secreted, Extracellular space |
| Subcellular Localization | Secreted, Extracellular space |
| Molecular Weight | 15 kDa |
| Pathways | PI3K, MAPK, TGF-β |
| UniProt ID | P39905 |
| GeneCards | GDNF |
| Human Protein Atlas | GDNF |
| Approach | Status |
| AAV-GDNF gene therapy | Clinical trials |
| GDNF protein infusion | Discontinued |
| GFRα1 agonists | Preclinical |
| Associated Diseases | ALS, APOPTOSIS, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety |
| Known Drugs/Compounds | levodopa, trehalose, rapamycin |
| Interactions | GFRAL, BDNF, GLP1R, SHH, ADCY3, LMX1A |
| SciDEX Hypotheses | GDNF Gradient Establishment by Schwann Cells Enabl |
| KG Connections | 782 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |