Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ascl1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ASCL1 |
| Full Name | Achaete-Scute Homolog 1 |
| Chromosome | 12p23.2 |
| Protein Type | Transcription Factor |
| Function | is a basic helix-loop-helix (bHLH) transcription factor essential for neural development, neurogenesis, and the differentiation of specific neuronal lineages. |
| Primary Expression | multiple developmental contexts: |
| Molecular Weight | 26.8 kDa |
| Amino Acids | 237 aa |
| UniProt ID | P50567 |
| NCBI Gene ID | 41 |
| Ensembl ID | ENSG00000139352 |
| OMIM | 100800 |
| GeneCards | ASCL1 |
| Human Protein Atlas | ASCL1 |
| Interactions | BDNF, GDNF, PRKN, LMX1A, NURR1 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ASCL1["ASCL1"]
ASCL1 -->|"regulates"| SEZ6["SEZ6"]
ASCL1 -->|"activates"| Carcinoma["Carcinoma"]
ASCL1 -->|"activates"| Cancer["Cancer"]
ASCL1 -->|"activates"| Schizophrenia["Schizophrenia"]
ASCL1 -->|"activates"| Aging["Aging"]
ASCL1 -->|"activates"| Depression["Depression"]
ASCL1 -->|"activates"| Bipolar["Bipolar"]
ASCL1 -->|"activates"| Ms["Ms"]
YAP["YAP"] -->|"activates"| ASCL1
CANCER["CANCER"] -->|"activates"| ASCL1
HNF4A["HNF4A"] -->|"regulates"| ASCL1
NGF["NGF"] -->|"activates"| ASCL1
UBIQUITIN["UBIQUITIN"] -->|"inhibits"| ASCL1
LMX1A["LMX1A"] -->|"activates"| ASCL1
GENES["GENES"] -->|"inhibits"| ASCL1
PRKN["PRKN"] -->|"activates"| ASCL1| Target | Relation | Type | Str |
|---|---|---|---|
| BDNF | activates | gene | 0.50 |
| GDNF | activates | gene | 0.50 |
| PRKN | activates | gene | 0.50 |
| LMX1A | activates | gene | 0.50 |
| NURR1 | activates | gene | 0.50 |
| Fibroblast | activates | cell_type | 0.50 |
| NEURONS | activates | concept | 0.50 |
| FIBROBLASTS | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NGN2 | associated_with | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| YAP1 | associated_with | gene | 0.60 |
| HNF4A | regulates | gene | 0.60 |
| NEUROD1 | associated_with | gene | 0.60 |
| NGF | activates | gene | 0.60 |
| UBIQUITIN | inhibits | gene | 0.60 |
| LMX1A | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PARKIN | inhibits | gene | 0.60 |
| GDNF | activates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| NURR1 | activates | gene | 0.60 |
| PTEN | therapeutic_target | gene | 0.60 |
| TP53 | therapeutic_target | gene | 0.60 |
| EZH2 | therapeutic_target | gene | 0.60 |
| SYP | therapeutic_target | gene | 0.60 |
| TRPV1 | regulates | gene | 0.60 |
| YAP | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| GENES | inhibits | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| PARKINSON | inhibits | gene | 0.60 |
| IL-1 | regulates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||