gene 2,282 words KG: LRFN1 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neurodegeneration
Contents

LRFN1 — Leucine Rich Repeat and Fibronectin Type III Domain Containing 1

🧬 Gene Info
Gene SymbolLRFN1
Full NameLeucine Rich Repeat and Fibronectin Type III Domain Containing 1
AliasesSALM1
Chromosome19q13.32
Functionis a neuronal synaptic adhesion molecule that plays critical roles in synapse formation, maintenance, and plasticity.
Primary Expressionthe central nervous system:
Subcellular LocalizationWithin neurons, LRFN1 localizes to:
Molecular Weight75 kDa
UniProt IDQ9ULJ8
NCBI Gene ID57608
Ensembl IDENSG00000171530
OMIM610099
GeneCardsLRFN1
Human Protein AtlasLRFN1
Alternative NamesSALM1, NLRR1
Associated DiseasesALS, Alzheimer, dementia, frontotemporal, neurodegeneration
KG Connections19 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
ALS Therapeutic Landscape — Programs by Phase and Modal
disease · Pages share 3 hypotheses
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses

Knowledge Graph (12 edges)

LRFN1 co_expressed_with MAPT
LRFN1 co_expressed_with RAB3B
LRFN1 associated_with neurodegeneration
LRFN1 associated_with frontotemporal
LRFN1 implicated_in NCAN
LRFN1 implicated_in RAB3B
LRFN1 implicated_in SLC1A2
LRFN1 implicated_in SYNPO
LRFN1 implicated_in TUBB2B
LRFN1 associated_with dementia