concept

FRONTOTEMPORAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRONTOTEMPORAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

577Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FRONTOTEMPORAL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S DISEASE. Connected to 113 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	FRONTOTEMPORAL
Key Genes/Proteins	ABCD3, ACTB, ALS4, AMBRA1, AMPK
Related Diseases	adrenoleukodystrophy, aging, ALS, ALZHEIMER, Alzheimer Disease

Pathway Diagram

graph TD
    FRONTOTEMPORAL["FRONTOTEMPORAL"]
    FRONTOTEMPORAL -->|"interacts"| FTD["FTD"]
    FRONTOTEMPORAL -->|"interacts"| FUS["FUS"]
    FRONTOTEMPORAL -->|"interacts"| LC3["LC3"]
    FRONTOTEMPORAL -->|"interacts"| OPTN["OPTN"]
    FRONTOTEMPORAL -->|"interacts"| P62["P62"]
    FRONTOTEMPORAL -->|"interacts"| SQSTM1["SQSTM1"]
    FRONTOTEMPORAL -->|"interacts"| STING["STING"]
    FRONTOTEMPORAL -->|"interacts"| UBIQUITIN["UBIQUITIN"]
    FRONTOTEMPORAL -->|"activates"| ULK1["ULK1"]
    FRONTOTEMPORAL -->|"causes"| HIF1A["HIF1A"]
    FRONTOTEMPORAL -->|"activates"| JNK["JNK"]
    FRONTOTEMPORAL -->|"activates"| MAPK["MAPK"]
    ALS["ALS"] -->|"interacts"| FRONTOTEMPORAL
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"interacts"| FRONTOTEMPORAL
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| FRONTOTEMPORAL
    BECN1["BECN1"] -->|"interacts"| FRONTOTEMPORAL
    C9ORF72["C9ORF72"] -->|"interacts"| FRONTOTEMPORAL
    DEMENTIA["DEMENTIA"] -->|"interacts"| FRONTOTEMPORAL
    ALZHEIMER["ALZHEIMER"] -->|"activates"| FRONTOTEMPORAL
    AMPK["AMPK"] -->|"activates"| FRONTOTEMPORAL
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| FRONTOTEMPORAL
    BCL2["BCL2"] -->|"regulates"| FRONTOTEMPORAL

Outgoing (161)

Target	Relation	Type	Str
FTD	accumulates_in	disease	0.65
NEURON	activates	cell_type	0.65
NEURONS	activates	cell_type	0.65
NEURODEGENERATION	causes	disease	0.65
NEURON	associated_with	cell_type	0.65
FTD	expressed_in	disease	0.65
MICROGLIA	contributes_to	cell_type	0.65
NEURODEGENERATION	contributes_to	disease	0.65
MOTOR NEURON	activates	cell_type	0.65
NEURONS	accumulates_in	cell_type	0.65
NEURON	accumulates_in	cell_type	0.65
TFEB	interacts_with	gene	0.60
NEURONS	associated_with	cell_type	0.60
FTD	causes	disease	0.60
OPTN	regulates	gene	0.60
VCP	activates	gene	0.60
FTD	associated_with	disease	0.60
MTOR	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
NEURON	causes	cell_type	0.60
TARDBP	interacts_with	gene	0.60
NEURONS	causes	cell_type	0.60
PYRAMIDAL	causes	cell_type	0.60
FUS	causes	gene	0.60
NEURON	interacts_with	cell_type	0.60
MAPT	causes	gene	0.60
FTD	regulates	disease	0.60
MICROGLIA	activates	cell_type	0.60
GLUTAMATERGIC	causes	cell_type	0.60
RB1	activates	gene	0.60
RIPK3	activates	gene	0.60
SNCA	activates	gene	0.60
SQSTM1	activates	gene	0.60
STING	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
HTT	associated_with	gene	0.60
LC3	causes	gene	0.60
MOTOR NEURON	causes	cell_type	0.60
MTOR	causes	gene	0.60
FTD	interacts_with	disease	0.60
FUS	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
STING	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ULK1	activates	gene	0.60
HIF1A	causes	gene	0.60
JNK	activates	gene	0.60

Incoming (416)

Source	Relation	Type	Str
FRONTAL	causes	brain_region	0.65
DEMENTIA	regulates	disease	0.65
ALZHEIMER	associated_with	disease	0.65
ALZHEIMER'S	associated_with	disease	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.65
DEMENTIA	biomarker_for	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
DEMENTIA	expressed_in	disease	0.65
ALS	biomarker_for	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	biomarker_for	disease	0.65
C9ORF72	associated_with	gene	0.65
ALZHEIMER'S	activates	disease	0.65
RAB7L1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
PARL	associated_with	protein	0.60
TAX1BP1	associated_with	gene	0.60
CALR	associated_with	gene	0.60
GRN	associated_with	gene	0.60
RAB3B	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
DDIT3	associated_with	gene	0.60
RHOT1	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
AMBRA1	associated_with	protein	0.60
PERK	associated_with	gene	0.60
MUL1	associated_with	gene	0.60
JNK	associated_with	protein	0.60
RTN3	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
EMD	associated_with	gene	0.60
BCL2L11	associated_with	gene	0.60
G3BP1	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
TUBB2B	associated_with	gene	0.60
CANX	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
LMNA	associated_with	gene	0.60
FAM134B	associated_with	gene	0.60
RB1	associated_with	protein	0.60
DRP1	associated_with	protein	0.60
DNM1L	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
FMR1	associated_with	gene	0.60
BNIP3L	associated_with	protein	0.60
MIRO1	associated_with	protein	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial TBK1 Deficiency Triggers Senescence-Associated Se	0.650	frontotemporal-dementia	-
ISR/eIF2α~P Overflow Represses Synaptic Proteostasis in Cort	0.650	frontotemporal-dementia	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FRONTOTEMPORAL in their description or question text

No additional research found