gene 509 words KG: MARCKS
Contents

MARCKS — Myristoylated Alanine-Rich Protein Kinase C Substrate

🧬 Gene Info
Gene SymbolMARCKS
Full NameMyristoylated Alanine-Rich Protein Kinase C Substrate
Chromosome6q21
Protein TypeKinase
Functionis a key substrate of Protein Kinase C (PKC) with critical roles in synaptic plasticity, cytoskeletal dynamics, and cell signaling[@hartwig1992][@sheetz2006].
Primary ExpressionBrain (neurons, glia), lung, spleen, immune cells
PathwaysPI3K/AKT/mTOR pathway
UniProt IDP29566
NCBI Gene ID4082
Ensembl IDENSG00000198237
OMIM177620
GeneCardsMARCKS
Human Protein AtlasMARCKS
Associated DiseasesAls, Ms
InteractionsPRKCH, TRIM1-269aa
KG Connections36 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (14)

Parkinson Basal Ganglia Circuit
circuit · KG edge: expressed_in
FUS (Redirect)
redirect · KG edge: associated_with
CD4 Gene
gene · KG edge: expressed_in
CTSK — Cathepsin K
gene · KG edge: expressed_in
IL1B Gene - Interleukin 1 Beta
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TRIM1-269aa interacts_with MARCKS
MARCKS activates PI3K/AKT/mTOR pathway
CD4 expressed_in MARCKS
CTSK expressed_in MARCKS
MARCKS associated_with APP
IL1B associated_with MARCKS
SOD2 associated_with MARCKS
MARCKS associated_with LAMP1
MARCKS associated_with MBP
MARCKS associated_with LAMP2

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