gene 509 words KG: MARCKS 2026-03-24
kind:genesection:genesstate:published
Contents

MARCKS — Myristoylated Alanine-Rich Protein Kinase C Substrate

🧬 Gene Info
Gene SymbolMARCKS
Full NameMyristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS, MACS)
AliasesMyristoylated Alanine-Rich Protein Kinase C Substrate
Chromosome6q21
Protein TypeKinase
Functionis a key substrate of Protein Kinase C (PKC) with critical roles in synaptic plasticity, cytoskeletal dynamics, and cell signaling[@hartwig1992][@sheetz2006].
Primary ExpressionBrain (neurons, glia), lung, spleen, immune cells
PathwaysPI3K/AKT/mTOR pathway
UniProt IDP29566
NCBI Gene ID4082
Ensembl IDENSG00000198237
OMIM177620
GeneCardsMARCKS
Human Protein AtlasMARCKS
Associated DiseasesAls, Ms
InteractionsTRIM1-269aa, PRKCH
KG Connections36 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45
Lysosomal Positioning Dynamics Modulation
Score: 0.43
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (14)

Fibroblast Growth Factor Signaling in Neurodegeneration
mechanism · KG edge: expressed_in
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
S100A9 - S100 Calcium Binding Protein A9
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MARCKS associated_with APP
MARCKS associated_with LAMP1
MARCKS associated_with MBP
MARCKS associated_with LAMP2
MARCKS associated_with S100A9
MARCKS associated_with IRF1
MARCKS associated_with FUS
MARCKS regulates SQSTM1
MARCKS expressed_in IMMUNE INFILTRATION
MARCKS expressed_in CANCER