gene 779 words KG: IRF1 2026-03-24
kind:genesection:genesstate:published
Contents

IRF1 Gene - Interferon Regulatory Factor 1

🧬 Gene Info
Gene SymbolIRF1
Full NameInterferon Regulatory Factor 1
AliasesPage for IRF1 Gene, Page for IRF1 Protein
Chromosome5q31.1
Protein TypeTranscription Factor
Functionis a transcription factor encoded by the IRF1 gene located on chromosome 5q31.
Molecular Weight36 kDa
Amino Acids325 aa
PathwaysAutophagy, Cell Cycle, Complement, Immune Response, Immunotherapy
UniProt IDP04855
NCBI Gene ID3659
Ensembl IDENSG00000125347
OMIM147575
GeneCardsIRF1
Human Protein AtlasIRF1
Associated DiseasesALS, Inflammation, Ms, Neuroinflammation
InteractionsCIITA, ATG5, CD8, NPM1, CALCOCO2, NDP52
KG Connections265 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.48
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

NPM1-IRF1 protein interaction validation
exploratory · proposed · Score: 0.90
IRF1 transcriptional regulation of Nlrc5 and Ciita promoters
exploratory · proposed · Score: 0.90
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (13)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: activates
CALM2 Gene
gene · KG edge: regulates
CALCOCO2 — Calcium Binding and Coiled-Coil Domain 2
gene · KG edge: inhibits

Knowledge Graph (12 edges)

IRF1 interacts_with NPM1
IRF1 activates CIITA
IRF1 inhibits ATG5
IRF1 activates CD8
IRF1 activates NPM1
IRF1 inhibits CALCOCO2
IRF1 inhibits NDP52
IRF1 activates TNF
IRF1 activates STAT1
IRF1 regulates RB1CC1