gene 766 words KG: SOD2 2026-03-24
kind:genesection:genesstate:published
Contents

SOD2 Gene

🧬 Gene Info
Gene SymbolSOD2
Full NameSuperoxide Dismutase 2, Mitochondrial
Chromosome6q25.3
FunctionSOD2 provides essential mitochondrial antioxidant defense
Molecular Weight22.3 kDa
Amino Acids222 aa
Exons5
PathwaysAkt, Apoptosis, Mapk, Mitochondrial Function, Mtor
NCBI Gene ID6648
Ensembl IDENSG00000112096
OMIM147460
GeneCardsSOD2
Human Protein AtlasSOD2
ApproachStrategy
SOD mimeticsEukarion, MitoQ
Associated DiseasesALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Cancer
Known Drugs/CompoundsLactiplantibacillus plantarum FRT4, resveratrol, berberine, RESVERATROL, BERBERINE
InteractionsFOXO1, ERK1, NOX4, SOD1, SOD3, SIRT3
KG Connections763 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (29)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
Mitochondrial Transfer Pathway Enhancement
Score: 0.44

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 8 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 8 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 8 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 8 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 8 hypotheses

Knowledge Graph (12 edges)

SOD2 therapeutic_target PPARGC1A
SOD2 therapeutic_target SIRT3
SOD2 therapeutic_target PRKAA1
SOD2 therapeutic_target CREBBP
SOD2 activates FOXO1
SOD2 associated_with CDC42
SOD2 associated_with CYCS
SOD2 associated_with GFAP
SOD2 therapeutic_target RAC1
SOD2 therapeutic_target MET