| Gene Symbol | IL1B |
| Full Name | Interleukin 1 Beta |
| Chromosome | 2q14.1 |
| Protein Type | Ligand |
| Target Class | Ligand |
| Function | IL-1 receptor antagonist or neutralizing monoclonal antibody |
| Mechanism of Action | IL-1 receptor antagonist or neutralizing monoclonal antibody |
| Druggability | Medium (0.49) |
| Clinical Stage | Approved |
| Molecular Weight | 31 kDa |
| Amino Acids | 269 aa |
| Exons | 7 |
| Pathways | Akt, Apoptosis, Epigenetic, Mapk, Oxidative Stress |
| UniProt ID | O43645 |
| NCBI Gene ID | 3553 |
| Ensembl ID | ENSG00000125538 |
| OMIM | 164520 |
| GeneCards | IL1B |
| Human Protein Atlas | IL1B |
| Associated Diseases | AD, Aging, Als, Alzheimer |
| Known Drugs/Compounds | ANTHOCYANINS, berberine, Berberine, Guhan Yangsheng Jing, HDAC3 inhibition, rapamycin |
| Interactions | A2M, ACACA, ACHE, ACTB, Actin, ADAM17 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Peripheral-to-Central Inflammation Circuit Breaker Neuroinflammation Biomarker-Guided Immunomodulatio |
| KG Connections | 1831 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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