gene 875 words KG: S100A9 2026-03-22
kind:genesection:genesstate:published
Contents

S100A9 - S100 Calcium Binding Protein A9

🧬 Gene Info
Gene SymbolS100A9
Full NameS100 Calcium Binding Protein A9
Chromosome1q21.3
Protein FamilyS100 calcium-binding protein family
FunctionS100A9, particularly as part of calprotectin (S100A8/A9), has diverse functions
Molecular Weight13.2 kDa
Amino Acids113 aa
Exons3
PathwaysNF-κB, MAPK signaling
GeneCardsS100A9
Human Protein AtlasS100A9
Associated DiseasesAls, Ms, Neuroinflammation, Sepsis, stroke
Known Drugs/CompoundsGW201
InteractionsBAX, EGFR, NLRP3, IL18, NLRP1, MMP2
KG Connections310 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: expressed_in
CCL3 Gene
gene · KG edge: activates
PPP3CA — Protein Phosphatase 3 Catalytic Subunit Alpha
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

S100A9 activates BAX
S100A9 associated_with S100A8
S100A9 activates ALDH1A1
S100A9 activates brain metastasis
S100A9 activates osimertinib resistance
S100A9 biomarker_for lung cancer progression
S100A9 expressed_in LC3
S100A9 associated_with IRF1
S100A9 associated_with MMP9
S100A9 regulates STAT6